Scientific programme

 
May 16, 2017
Day 1 / Opening session
16:00-22:00
Registration
16:00-18:20
CIS
0
16:00

Arrival, Registration and Poster set up 


0
18:00

Welcome Organizers


Session 1: (Em)Powering the SASP
18:20-21:10
CIS
ZHANG Rugang,
1
18:20

The kaleidoscope of cellular senescence

J. Campisi
Buck Institute for Research on Aging, United States 
2
19:10

Senescence associated pattern recognition receptors in control of oncogene induced senescence

J. Acosta
ECRC, MRC-Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 
3
19:25

Innate immune sensing of chromatin through cGAS regulates the SASP

A. Ablasser
Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
4
19:40

Integrin beta3 regulates senescence by activating TGF-b in a paracrine and autocrine fashion

M. Borghesan1, V. Rapisarda1, V. Miguela3, V. Encheva2, P. Snijders2, A. Lujambio3, A. O'loghlen1
1Queen Mary University 2The Francis Crick Institute, London, United Kingdom 3Icahn School of Medicine at Mount Sinai, New York, United States 
5
19:55

Uncoupling senescence-assocaited cell cycle exit from SASP production in oncogenesis

L. Lau, A. Bainor, A. Porciuncula, M. Reilland, M. Miller, S. Logan, G. David
New York University School of Medicine, New York, United States 
6
20:10

The senescence-associated secretory phenotype bridges tissue ischemia to pathological angiogenesis in retinopathy

M. Oubaha1, K. Miloudi1, A. Dejda1, V. Guber1, G. Mawambo1, M.A. Germain1, G. Bourdel1, N. Popovic1, F.A. Rezende1, R.J. Kaufman2, P. Sapieha1, F. Mallette1
1Maisonneuve-Rosemont Research Center, Université de Montréal, Montréal, Canada 2Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States 
7
20:25

p53 in bronchial Club cells facilitates chronic lung inflammation by promoting senescence

A. Sagiv3, A. Bar-Shai2-1, N. Feldman3, A. Ronen2, V. Krizhanovsky3
1Institute of Pulmonology, Barzilai Medical Center, Ashkelon 2Department of Immunology 3Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 
8
20:40

Metabolic basis of cellular senescence

R. Zhang
The Wistar Institute, United States 
Welcome cocktails
21:10-22:00
May 17, 2017
Day 2 / Senescence Triggers
08:30-18:50
CIS
Session 2.1 : DNA Damage Response and Telomeres
08:30-10:00
HERBIG Utz,
0
08:30

ICSA Assembly


9
09:00

Epigenetic stress response and stem cell aging

L. Rudolph
Beutenbergstraße 11, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany 
10
09:30

A fresh look at senescence associated persistent DNA breaks in mammalian cells and tissues

A. Galbiati2, C. Beauséjour2, F. D'adda Di Fagagna2-3
1Département de Pharmacologie, CHU Ste-Justine, Montréal, Canada 2IFOM, Milan 3Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy 
11
09:45

Cellular senescence drives age-dependent hepatic steatosis

M. Ogrodnik7, S. Miwa7, T. Tchkonia8, D. Tiniakos7, C. Wilson7, A. Lahat4, C. Day7, A. Burt1, A. Palmer8, Q. Anstee7, S. Grellscheid4, D. Mann7, J. Hoeijmakers2-3, S. Barnhoorn3, T. Bird6-5, W. Vermeij3, J. Kirkland8, J. Passos7, T. Zglinicki7, D. Jurk7
1University of Adelaide, Adelaide, Australia 2CECAD University Cologne, Cologne, Germany 3Erasmus University Medical Centre, Rotterdam, The Netherlands 4Durham University, Durham 5University of Edinburgh, Edinburgh 6CRUK Beatson, Glasgow 7Newcastle University Instiute for Ageing, Newcastle University, Newcastle Upon Tyne, United Kingdom 8Mayo Clinic, Rochester, Mn, United States 
Coffee break
10:00-10:30
Session 2.2 : DNA Damage Response and Telomeres
10:30-12:55
0
10:30

Welcome Address by M. Christian Bréchot, General Director of Institut Pasteur


12
10:40

Telomere dysfunction-induced senescence and its impact on human health

U. Herbig
Rutgers University, United States 
13
11:10

Investigating the role of neutrophil infiltrations in DNA-damage induced senescence

A. Lagnado2, F. Oakley1, C. Wilson1, D. Jurk2, M.H. Ruchaud-Sparagano1, J. Birch2, D. Mann1, J.F. Passos2
1Institute for Cell and Molecular Biosciences (ICaMB) 2Campus for Ageing and Vitality, Newcastle University Institute for Ageing, Newcastle Upon Tyne, France 
14
11:25

Monoamine oxidases as molecular players of cardiac senescence

N. Manzella1-2, D. Maggiorani1, C. Binda2, A. Mattevi2, F. Lezoualc’h1, A. Parini1, J. Mialet Perez1
1UMR1048 Institute of Metabolic and Cardiovascular Diseases, INSERM, Toulouse, France 2Department of Biology and Biotechnology "L. Spallanzani“, University of Pavia, Pavia, Italy 
15
11:40

Redefining entry into telomere-mediated replicative senescence: Uncapping or irreparable genome damage?

M.A. Olivier1-2, S. Ghadaouia1-2, A. Martinez1-2, N. Malaquin1-2, G. B Cardin1-2, F. Rodier1-2-3
1Centre de recherche du CHUM (CRCHUM) 2Institut du cancer de Montréal (ICM) 3Département de radiologie, radio-oncologie et médicine nucléaire, Université de Montréal, Montréal, Canada
16
11:55

Frequent adaptation events in telomerase-negative cells drive genome instability in senescence

Z. Xu1, H. Coutelier1, M. Chenda1, P. Jolivet1, S. Pelet3, G. Charvin2, M.T. Teixeira1
1Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, CNRS - Institut de Biologie Physico-Chimique, Paris 2IGBMC, Strasbourg, France 3Département de Microbiologie, Université de Lausanne, Lausanne, Switzerland 
17
12:10

Escaping cellular senescence by targeting telomerase expression in damaged cells: consequences for lung diseases

V. Geli2, F. Jourquin2, M. Breau1, R. Castellano2, S. Abid1, S. Bauwens, I. Flores4, E. Gilson3, S. Adnot1
1INSERM U955 Equipe 8, Faculté de Médecine de Créteil, Creteil 2CRCM Marseille, Inserm-CNRS, Marseille 3IRCAN, Nice, France 4Regeneration and Aging group, Spanish National Center for Cardiovascular Research, Madrid, Spain 
18
12:25

Length-independent telomere damage drives cardiomyocyte senescence

J. Passos
Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle Upon Tyne, United Kingdom 
Lunch
12:55-14:00
Session 3.1: Transcriptional Regulation and Gene Networks
14:00-16:00
GOROSPE Myriam, Baltimore
19
14:00

Profound nuclear and chromatin alterations in senescence and aging

S. Berger
Perelman School of Medicine, University of Pennsylvania, United States 
20
14:30

Single cell transcriptomics reveals heterogeneity in oncogene-induced senescence

Y.V. Tee3, K. Kirschner1, A. Green1, N. Neretti3, T. Chandra2
1Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge 2MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 3Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, United States 
21
14:45

Uncovering regulators of irreversible growth arrest during therapy induced senescence

M. Klein1-5-4, M. Kovatcheva4, W. Tap6-2, S. Singer3, A. Crago3, A. Koff4
1Andrew Koff Lab 2Department of Medicine 3Department of Surgery 4Program in Molecular Biology 5The Louis V. Gerstner Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center 6Department of Medicine, Weill College of Medicine, Cornell University, New York, United States 
22
15:00

Cell-cell communication in senescence

M. Narita
Cancer Research UK Cambridge Institute, Cambridge, United Kingdom 
23
15:30

Age-associated alterations in haematopoietic stem cell heterochromatin

D. Garrick2, D. Djeghloul2, I. Kuzniak2, K. Kuranda2, D. Barbieri3, F. Porteu3, I. Naguibneva1, M. Goodhardt2
1INSERM UMRS 967, Institut de Radiobiologie Cellulaire et Moléculaire, Commissariat à l'Energie Atomique, Fontenay-Aux-Roses 2INSERM UMRS 1126, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris 3INSERM UMRS 1170, Gustave Roussy Cancer Campus, Université Paris Sud - Université Paris-Saclay, Villejuif, France 
24
15:45

Signatures of senescence progression in a transcriptomic landscape analysis across the mouse lifespan

A. Lahat1, D. Dolan1, S. Miwa3, M. Ogrodnik3, A. Enright2, T. Von Zglinicki3, S. Grellscheid1
1Department of Biosciences, Durham University, Durham 2EMBL-EBI, Hinxton 3NUIA, Newcastle University, Newcastle, United Kingdom 
Coffee break
16:00-16:30
Session 3.2: Transcriptional Regulation and Gene Networks
16:30-18:30
25
16:30

Control of cell senescence by HuR and target noncoding RNAs

M. Gorospe, K. Abdelmohsen, A.C. Panda, I. Grammatikakis, J.H. Noh
Laboratory of Genetics and Genomics, NIH - National Institute on Aging, Baltimore, United States 
26
17:00

A senescence-specific lncRNA modulates the pro-inflammatory response of senescent cells

E. Grossi1-2, D. Martínez Herrera1-2, F. Marchese1-2, N. Herranz3, J. Gil3, M. Huarte1-2
1Gene Therapy and Regulation of Gene Expression, CIMA 2IdiSNA, Health Research Institute of Navarra, Pamplona, Spain 3Cell Proliferation Group, MRC, Imperial College London, London, United Kingdom 
27
17:15

The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling

X. Ma1, M. Warnier1, M. Ferrand1, O. Kirsh2, P.A. Defossez2, N. Martin1, D. Bernard1
1Senescence Escape Mechanisms team, Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon 2Epigenetics and Cell Fate unit, UMR 7216 CNRS, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
28
17:30

A dynamic transcription factor (TF) network controls the oncogene-induced senescence (OIS) gene expression programme

R.I. Martínez Zamudio, P.F. Roux, O. Bischof
ONO, Institut Pasteur, Paris, France 
29
17:45

HMGB-family members topologically bookmark the genome and control senescence-induced three-dimensional reorganization via CTCF

A. Zirkel, M. Nikolic, K. Sofiadis, A. Papantonis
Center for Molecular Medicine, University of Cologne, Cologne, Germany 
30
18:00

Systems biology: from understanding towards controlling of complex biological networks

K. Cho
Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, KAIST, Daejeon, South Korea 
Posters Flash talk
18:30-18:50
1
18:30

Isolation and characterization of senescence-associated exosomes

S. Da Silva-Alvarez5, A. Ferreirós5, P. Pedrosa-Lado5, F. Triana-Martínez5, P. Cabezas-Sainz1, C. De Lope3, G.N. Condezo2, P. Ximénez-Embún4, C. San Martín2, J. Muñoz4, M. González-Barcia6, L. Sánchez1, I. Palmero3, M. Collado5
1Genetics Department, Veterinary Faculty, Lugo 2Department of Macromolecular Structures, Spanish National Center of Biotechnology (CNB-CSIC) 3Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM 4Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid 5Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela (CHUS) 6Xerencia de Xestión Integrada de Santiago de Compostela, Servicio de Farmacia, Santiago De Compostela, Spain 
2
18:32

Non-canonical inflammasome activation regulates oncogene-induced senescence

I. Fernandez-Duran, P. Hari, N. Tarrats, J.C. Acosta
Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 
3
18:34

Regulatory role of PARP-1 in the onset and maintenance of oncogene induced senescence

L. Robinson, R. Martinez-Zamudio, P.F. Roux, G. Dore, O. Bischof
Cell Biology, ONO, Anne Dejean, Oliver Bischof, Institut Pasteur, Paris, France 
4
18:36

Non-autonomous regulation of chromatin structure by NOTCH1

A. Parry1, M. Hoare1, R. Hansel-Hertsch1, D. Bihary2, S. Samarjiwa2, M. Narita1
1Narita Lab, CRUK CI, Li Ka Shing Centre, University of Cambridge, Cancer Research UK Cambridge Institute 2University of Cambridge, MRC Cancer Cell Unit, Cambridge, United Kingdom 
5
18:38

Global sumoproteome analysis reveals a PML-localized network of proteins regulating cellular senescence

F.P. Mcmanus, V. Bourdeau, M. Acevedo, S. Lopes-Paciencia, F. Lamoliatte, P. Thibault, G. Ferbeyre
biochimie et médecine moléculaire, Université de Montréal, Montréal, Canada 
6
18:40

Inhibition of the 60S ribosome biogenesis GTPase LSG1 induces senescence with a restricted senescence-associated secretory phenotype

A. Pantazi, A. Quintanilla, T. Chandra, J.C. Acosta, A. Finch
Edinburgh Cancer Research Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom 
7
18:42

Investigating the role of p21 in the regulation of developmental senescence

D. Amaya, M. Rhinn, W. Keyes
Development and stem cells, Institut de génétique et de biologie moléculaire et cellulaire, Illkirch-Graffenstaden, France 
8
18:44

Role of integrin beta 3 in ageing

J. Fafián Labora, P. Carpintero-Fernandez, M. Borghesan, V. Rapisarda, A. O'loghlen
Epigenetic Senescence Cellular Group, Queen Mary University of London, Blizard Institute, London, United Kingdom 
9
18:46

Proteotoxicity links therapy-induced cancer cell senescence to Alzheimer’s disease

D. Dhawan1-2, K. Schleich2, C.A. Schmitt1-2, S. Lee1-2
1Berlin School of Integrative Oncology 2Hematology, Oncology and Tumor Immunology, Campus Virchow, Charité - Universitätsmedizin Berlin, Berlin, Germany 
10
18:48

Can the inflammatory facet of SASP be controlled?

P. D'alessio3, J.F. Bisson2, M.V. Ursini4, M.C. Bene1
1Hematology Biology, Nantes University Hospital, Nantes 2allée du morvan, ETAP, Vandoeuvre Les Nancy 3Biopark 1 mail Pr Georges Mathé, AISA, Villejuif, France 4CNR - IGB, Naples, Italy 
Poster session - Open bar
18:50-21:00
May 18, 2017
Day 3 / Physiological Functions of Senescence
08:30-18:30
Session 4.1: Tissue Regeneration
08:30-10:00
KEYES Bill, Illkirch Cedex
31
08:30

Senescence induced plasticity in regeneration and cancer

B. Keyes
CNRS UMR 7104 - Inserm U 964, IGBMC, Illkirch Cedex, France 
32
09:00

Rejuvenation of senescent fibroblast morphology, proteome and replicative lifepsan by modulating mTOR and cytoskeletal signalling

L. Cox, H. Walters
Department of Biochemistry, University of Oxford, Oxford, United Kingdom 
33
09:15

Heat shock induces cellular senescence and SASP in human skin fibroblasts

S. Kerschbaum, C. Wegrostek, E. Riegel, T. Czerny
Department of Applied Life Sciences, University of Applied Sciences, Vienna, Austria 
34
09:30

Injury-induced senescence enables in vivo reprogramming in skeletal muscle

A. Chiche2, I. Le Roux1, M. Von Joest2, H. Sakai3, S. Bua2, C. Cazin2, L. Fiette4, O. Alegria2, P. Flamant4, S. Tajbakhsh3, H. Li2
1Institut du Cerveau et de la Moelle epiniere 2Developmental and stem cells dept, Cellular Plasticity and Disease Modelling group (G5) 3Developmental and stem cells dept, Stem cells & Development Unit 4Human Histopathology and Animal Models, institut Pasteur, Paris, France 
35
09:45

Cardiomyocyte-cardiac fibroblast directed crosstalk induces myofibroblast senescence to control fibrogenesis

K. Meyer2-1, I. Ognenoska, D. Ramanujam2-1, S. Engelhardt2-1, A. Sarikas2-1
1German Centre for Cardiovascular Research (DZHK) 2Institute of Pharmacology and Toxicology, Technical University Munich, Munich, Germany 
Coffee break
10:00-10:30
Session 4.2: Tissue Regeneration
10:30-12:30
36
10:30

The interplay between senescence and regeneration: insights from the salamander

M. Yun
University College London - IRIS, United Kingdom 
37
11:00

Identification of novel mechanisms of immune surveillance of senescent cells

Y. Ovadya2, I. Datta2, N. Papismadov2, H. Gal2, R. Yosef2, N. Pilpel2, A. Biran2, Y. Levin1, V. Krizhanovsky2
1Israel National Center for Personalized Medicine 2Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 
38
11:15

IR-induced senescence of the splenic microenvironment impacts murine immune cells functions

L. Palacio1-2, S. Bourbonnais1, N. Villeneuve1, G. Moquin-Beaudry1-2, O. Le1-2, H. Decaluwe1-2, C. Beauséjour1-2
1Departement de pharmacologie, Université de Montreal, Centre de recherche du Centre Hospitalier Universitaire Ste-Justine 2Université de Montreal, Montreal, Canada 
39
11:30

Ionizing radiation-induced endothelial senescence and role in normal tissue injury

F. Soysouvanh3, J. Lavigne3, M. Mondini4, M. Dos Santos2, V. Buard3, G. Tarlet3, M. Benadjaoud2, S. Adnot1, E. Deutsch4, O. Guipaud3, V. Paget3, A. François3, F. Milliat3
1U955, Université Paris-Est Créteil, Créteil 2PRP-HOM/SRBE 3PRP-HOM/SRBE/L3R, Institut de Radioprotection et de Sûreté Nucléaire, Fontenay-Aux-Roses 4U1030, Institut Gustave Roussy, Villejuif, France 
40
11:45

Novel IL6 family member is an inducer of quiescence that augments muscle stem cell engraftment and regeneration

A. Palla2, S. Sampath2-1, S. Sampath2-1, A. Ho2, S. Corbel2-1, C. Schmedt1, H. Blau2
1Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego 2Baxter Laboratory for Stem Cell Biology, Stanford University, Stanford, United States 
41
12:00

Accumulation of senescent cells - mechanisms and consequences

Y. Ovadya, V. Krizhanovsky
Weizmann Institute of Science, Israel 
Lunch
12:30-14:00
Session 5.1 : Tumor Suppression
14:00-16:00
BERTOLOTTO Corine, Nice
42
14:00

The ZEB1 EMT-inducing transcription factor establishes a link between the escape from oncogene-induced senescence and the genetic history of breast tumorigenesis

A. Puisieux
UMR INSERM 1052 CNRS 5286, Centre de Recherche en Cancérologie de Lyon, Lyon Cedex 08, France 
43
14:30

Mitotic-slippage induced senescence confers a pro-tumourigenic phenotype

B. Cheng
Lee Kong Chian School of Medicine, Karen Crasta Lab, Nanyang Technological University, Singapore, China 
44
14:45

Senescence and immunotherapy in cancer mediated by Stat3 blockade

M. De Martino1, M. Tkach2, M.F. Mercogliano1, M.F. Chervo1, C.J. Proietti1, P.V. Elizalde1, E. Piaggio2, R. Schillaci1
1Laboratory of Molecular Mechanisms of Carcinogenesis, IBYME-CONICET, Buenos Aires, Argentina 2INSERM U932, Institut Curie, Paris, France 
45
15:00

The transcription factor Spi1/PU.1 limits proliferation by inducing cellular senescence during hematopoiesis, a process that is lost during early steps of leukemic transformation

L. Delestre2, H. Cui2, V. Penard-Lacronique2, O. Bischof1, C. Guillouf2
1Unit of Nuclear Organization and Oncogenesis, Institut Pasteur, Paris 2Inserm U1170, Gustave Roussy, Villejuif, France 
46
15:15

Senescent human breast fibroblasts after exposure to ionizing radiation have an altered proteoglycan expression facilitating tumor progression

A. Papadopoulou2, E. Mavrogonatou2, E. Liakou2, H. Pratsinis2, P. Panagiotou1, V. Gorgoulis3, N. Karamanos4, D. Kletsas2
1KAT Hospital 2Laboratory of Cell Proliferation and Ageing, NCSR "Demokritos" 3Medical School, University of Athens, Athens 4University of Patras, Patras, Greece 
47
15:30

Oncogenic MITFE318K promotes senescence delay and melanoma progression

C. Bertolotto
INSERM U1065, Nice, France 
Coffee break
16:00-16:30
Session 5.2 : Tumor Suppression
16:30-18:25
48
16:30

Molecular insights of APL cure as therapy-induced senescence

M. Ogrunc2, A.L. Maubert2, H. De Thé1
1College de France 2U944, INSERM, Paris, France 
49
16:45

Interplay of CIP2A inhibition-induced senescent tumor cells and tumor infiltrating immune cells in basal-like breast cancer

A. Laine6, O. Kauko4, H. Sihto2, P. Kronqvist5, H. Joensuu1, J. Westermarck4-3, K. De Visser6
1Department of Oncology, Helsinki University Hospital and University of Helsinki 2Laboratory of Molecular Oncology, Molecular Cancer Biology Program, Biomedicum; Department of Oncology, University of Helsinki, Helsinki 3Department of Pathology 4Turku Centre for Biotechnology, University of Turku 5Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland 6Division of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands 
50
17:00

Cytokine-induced senescence proceeds via an argonaute protein 2-dependent mechanism

M. Rentschler2, T. Wieder2, Y. Chen2, H. Braumüller2, J. Pahl2, E. Brenner2, S. Weidemann2, O. Bischof1, M. Röcken2
1Institut Pasteur, Paris, France 2Dermatology, University Medical Center Tübingen, Tübingen, Germany 
51
17:15

Identification of a new phosphorylation site on SOCS1 involved in the regulation of cellular senescence

E. Saint-Germain, L. Mignacca, F. Lessard, M. Acevedo, M. Rowell, K. Moineau-Vallée, V. Calabrese, V. Bourdeau, G. Ferbeyre
Biochemistry, Gerardo Ferbeyre lab, Université de Montréal, Montreal, Canada 
52
17:30

H3K9-active demethylases disable oncogene-induced senescence and promote melanomagenesis

Y. Yu4, M. Silvis9, K. Kemper8, P. Lohneis3, N. Qutob7, M. Werner-Klein5, S. Meierjohann6, B. Dörken2, S. Holmen9, D. Peeper8, Y. Samuels7, S.Y. Lee4-2-1, C. Schmitt4-2-1
1Berlin Institute of Health 2Department of Hematology and Oncology 3Department of Pathology, Charité - University Medical Center 4Max delbrueck center for molecular medicine, Berlin 5Institute for Immunology, University Regensburg, Regensburg 6Physiological Chemistry, University of Würzburg, Würzburg, Germany 7Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 8Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands 9Huntsman Cancer Institute, University of Utah, Salt Lake City, United States 
53
17:45

Modeling release from oncogene-induced senescence

M. Bosenberg
Yale University, United States 
54
18:15

Advances in chromatin immunoprecipitation

C. Proux
Active Motif Europe S.A., La Hulpe, Belgium 
Group photo
18:25-18:35
Poster session - Open bar
18:35-21:30
May 19, 2017
Day 4 / Pathologies and Therapies
08:30-19:00
Session 6.1: Age-related Diseases and Pathological Consequences
08:30-10:00
ADNOT Serge,
55
08:30

Role of cellular senescence in chronic lung diseases

S. Adnot
Institut Mondor de Recherche Biomedicale, France 
56
09:00

Contribution of in vivo senescent cells to age-related diseases

D. Baker
Mayo Clinic, Rochester, United States 
57
09:15

Antioxidant treatment can promote lung tumor formation during chronic oxidative stress

M. Breau3, E. Marcos3, A. Parpaleix3, S. Abid3, A. Houssaini3, E. Bizard3, L. Boyer2, J. Tran-Van-Nhieu1, F. Mechta-Grigoriou5, D. Bernard4, S. Adnot3
1Dept of Pathology, Henri Mondor Hospital 2Team 4, Créteil 3Team 8, INSERM U 955, Créteil Cedex 4INSERM 1052 CNRS 5286, Leon Berard Center, Lyon 5Stress and Cancer Lab, Curie Institut, Paris, France 
58
09:30

Targeted therapy-induced senescence enhances immune surveillance of KRAS mutant lung cancers

M. Ruscetti3, J. Leibold3, M. J. Bott3, C.C. Chen3, M. Fennell3, T. Baslan3, E. Manchado3, E. De Stanchina4, C. J. Sherr2-1, S. W. Lowe3-1
1Howard Hughes Medical Institute, Chevy Chase, MD 20815 2Department of Tumor Cell Biology, St. Jude Children’s Research Hospital, Memphis, TN 38105 3Department of Cancer Biology and Genetics 4Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States
Coffee break
10:00-10:30
Session 6.2: Age-related Diseases and Pathological Consequences
10:30-12:15
59
10:30

HDAC inhibitors impair the pro-inflammatory senescence-associated secretory phenotype by blocking the nuclear-cytoplasmic translocation of damage DNA fragments

M.G. Vizioli1, Z. Dou3, N. Robertson1, A. Lagnado2, T. Bird1, J. Passos2, S. Berger3, P. Adams1
1Epigenetics, The Beatson Institute for Cancer Research, Glasgow 2Institute for Ageing and Cancer, Newcastle, United Kingdom 3Department of Cell and Development Biology, Perelman School of Medicine, Philadelphia, United States 
60
10:45

Insights into haematopoietic stem cell ageing and disease from single cell studies

K. Kirschner
Beatson Institute for Cancer Research, University of Glasgow, Glasgow, United Kingdom 
61
11:00

Neuregulin-1 attenuates stress-induced vascular senescence in vitro and in vivo

H. Shakeri3, K. Lemmens3, A. Gevaert3-2, V. Segers3-1
1Department of Cardiology, University Hospital Antwerp, Belgium 2Laboratory for Cellular and Molecular Cardiology, Department of Cardiology, University Hospital Antwerp, Belgium 3dep. medicine, pharmacology, physiopharmacology, university of Antwerp, Antwerp, Belgium 
62
11:15

Osteoporosis

F. Jakob
Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Würzburg, Germany 
63
11:45

Combining senescence with biomaterials research and biofabrication for regenerative medicine

J. Groll
University of Wuerzburg, Germany 
Lunch
12:15-13:30
Session 7.1: Biomedical Exploitation
13:30-15:30
ALIMONTI Andrea, Bellinzona
64
13:30

Targeting the cancer genome and the tumour immune response for pro-senescence therapy

A. Alimonti
Institute of Oncology Research, Bellinzona, Switzerland 
65
14:00

Evaluation of a novel ß-Galactosidase specific PET tracer for in vivo imaging of tumor senescence

M. Krueger2, J. Cotton2, A. Kuehn2, K. Fuchs2, B. Zhou2, A. Maurer2, K. Wolter1, L. Zender1, B. Pichler2
1Division of Molecular Oncology of Solid Tumors, Department of Internal Medicine 2Werner Siemens Imaging Center, University Hospital Tuebingen, Tuebingen, Germany 
66
14:15

Nanotechnology-based approaches for targeting senescent cells: defining novel therapeutic strategies

A. Ekpenyong-Akiba, M. Althubiti, M. Casulleras, L. Castilla, B. Abd, F. Canfarotta, S. Piletsky, S. Macip
University of Leicester, Leicester, United Kingdom 
67
14:30

Selectively targeting the ribosome: a novel pro-senescence therapeutic strategy for p16+ Basal-like breast cancer

M. Moore, M. Philpott, C. Bishop
Cell Biology and Cutaneous Research, The Blizard Institute, Queen Mary, University of London, London, United Kingdom 
68
14:45

Induction of ribosomal checkpoint induced senescence (RCIS) for the treatment of liver cancer

K. Wolter3-1, M. Pesic3-1, P.K. Premsrirut4, A. Poso3-1, L. Zender3-1-2
1Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany, 72076 Tübingen 2Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg 3Department of Internal Medicine VIII, University Hospital Tübingen, Tübingen, Germany 43Mirimus Inc., New York, United States 
69
15:15

Novel diagnostic tools for lung cancer early detection

D. Munoz-Espin3-1, M. Rovira1, B. Lozano2, I. Galiana2, C. Giménez2, S. Llanos1, S. Chaib1, M. Muñoz1, A. Bernardos2, J.R. Murguía2, R. Martínez-Máñez2, M. Serrano1
1Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 2Inter University Research Institute for Molecular Recognition and Technological Development (IDM), Polytechnic University of Valencia (UPV), Valencia, Spain 3Oncology, University of Cambridge, Cambridge, United Kingdom 
Coffee break
15:30-16:00
Session 7.2: Biomedical Exploitation
16:00-17:30
70
16:00

A one-two punch model for the treatment of cancer

R. Bernards, L. Wang, R. Leite D'oliveira, C. Wang
Netherlands Cancer Institute, Amsterdam, The Netherlands 
71
16:30

Defects specific to progeroid Cockayne syndrome cells are recapitulated during normal cellular senescence

C. Crochemore, L. Chatre, M. Ricchetti
Stem Cells & Development, CNRS UMR3738 Team Nuclear & Mitochondrial DNA Stability, Institut Pasteur, Paris, France
72
16:45

Closing Lecture:Keynote Lecture

Tissue repair: an integrated view of senescence and reprogramming

M. Serrano
Spanish National Cancer Research Centre (CNIO), Madrid, Spain 
0
17:15

Poster prize


Public Session Panel Expert: Peter Adams, Serge Adnot, Oliver Bischof, Myriam Gorospe, Maximina Yun, Clemens Schmitt, Manuel Serrano
17:30-19:00
GILSON Eric, Nice
Banquet "Senescence-on-the-Seine"
20:30-02:00

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